Synthesis by Click Reactions and Antiplasmodial Activity of Lupeol 1,2,3-Triazole Derivatives
نویسندگان
چکیده
منابع مشابه
Synthesis and Antitubercular activity of novel lupeol derivatives
Recently, one third of the world’s population is infected with Mycobacterium tuberculosis and 8 million new and relapse cases of tuberculosis are reported every year. The emergence of new cases, the increased incidence of multidrug resistant strains of M. tuberculosis, and the adverse effects of first and second-line antituberculosis drugs have led to renewed research interest in natural produc...
متن کاملIsolation of Lupeol, Design and Synthesis of Lupeol Derivatives and their Biological Activity
The triterpenoid, lupeol (1) has been isolated from the leaves extract of Walsura trifoliate. Few novel derivatives (4a–j) were synthesized from the naturally occurring lupeol (1) and confirmed by spectroscopic methods, and tested for antimicrobial and anti-proliferative activity against MDAMB231, IMR32and A549 cell lines. This all compound showed moderate activities.
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Malaria remains one of the most deadly diseases threatening humankind and is still affecting a significant proportion of the world population, especially in Africa. Chemotherapy is a vital component of the fight against the disease and new antimalarial agents are urgently needed to curb the spread of malaria parasites that are resistant to existing drugs. The natural product tryptanthrin is kno...
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Some synthetic 1-azabenzanthrones (7H-dibenzo[de,h]quinolin-7-ones) are weakly to moderately cytotoxic, suggesting that they might also show antiparasitic activity. We have now tested a small collection of these compounds in vitro against a chloroquine-resistant Plasmodium falciparum strain, comparing their cytotoxicity against normal human fibroblasts. Our results indicate that 5-methoxy-1-aza...
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Objective(s): Due to the rapid increased drug resistance to Plasmodium parasites, an urgent need to achieve new antiplasmodial drugs is felt. Therefore, in this study, the new synthetic phenanthroline derivatives were synthesized with antiplasmodial activity. Materials and Methods: A series of 1,10-phenanthroline derivatives containing amino-alcohol and amino-ether substituents were synthesized...
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ژورنال
عنوان ژورنال: Journal of the Brazilian Chemical Society
سال: 2017
ISSN: 0103-5053
DOI: 10.21577/0103-5053.20170013